WebJun 10, 2024 · NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt (II) complex, [Pt (ƞ 1 -C 2 H 4 OMe) (DMSO) (phen)] + (phen = 1,10-phenanthroline), Pt-EtOMeSOphen, was synthesized and studied for its antitumor activity against eight … WebApr 9, 1999 · The direct detection of 195 Pt- and 15 N-NMR signals was widely used in early studies of reactions of cis -diamminedichloroplatinum (II) ( cis -DDP) with various biomolecules. The 195 Pt chemical shift is sensitive to the nature of the bound donor atoms as well as to geometrical isomerism and chiral centres.
195Pt‐ and 15N‐NMR Spectroscopic Studies of Cisplatin …
WebOct 22, 2024 · NMR and LCMS analysis highlighted choline, creatine, phosphocholine, valine, acetic acid, phenylalanine, leucine, glutamic acid, threonine, uridine and proline … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … aspirasi darah adalah
Exo-Functionalized Metallacages as Host-Guest Systems for the ...
WebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... Web195Pt and 15N nuclear magnetic resonance (NMR) was used to study the chemical equilibria of cisplatin in water and plasma ultrafiltrate (PUF). Cisplatin was found to be … WebSep 19, 2009 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is used in chemotherapy where platinum–DNA adducts initiate tumor cell death. It is possible that side effects such as neurotoxicity and cellular cisplatin resistance can be due to interaction of cisplatin with lipids and the phospholipid bilayer. aspirasi in english