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Cisplatin nmr

WebJun 10, 2024 · NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt (II) complex, [Pt (ƞ 1 -C 2 H 4 OMe) (DMSO) (phen)] + (phen = 1,10-phenanthroline), Pt-EtOMeSOphen, was synthesized and studied for its antitumor activity against eight … WebApr 9, 1999 · The direct detection of 195 Pt- and 15 N-NMR signals was widely used in early studies of reactions of cis -diamminedichloroplatinum (II) ( cis -DDP) with various biomolecules. The 195 Pt chemical shift is sensitive to the nature of the bound donor atoms as well as to geometrical isomerism and chiral centres.

195Pt‐ and 15N‐NMR Spectroscopic Studies of Cisplatin …

WebOct 22, 2024 · NMR and LCMS analysis highlighted choline, creatine, phosphocholine, valine, acetic acid, phenylalanine, leucine, glutamic acid, threonine, uridine and proline … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … aspirasi darah adalah https://themarketinghaus.com

Exo-Functionalized Metallacages as Host-Guest Systems for the ...

WebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... Web195Pt and 15N nuclear magnetic resonance (NMR) was used to study the chemical equilibria of cisplatin in water and plasma ultrafiltrate (PUF). Cisplatin was found to be … WebSep 19, 2009 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is used in chemotherapy where platinum–DNA adducts initiate tumor cell death. It is possible that side effects such as neurotoxicity and cellular cisplatin resistance can be due to interaction of cisplatin with lipids and the phospholipid bilayer. aspirasi in english

A NMR-Based Metabolomic Approach to Investigate the Antitumor ... - Hindawi

Category:Monofunctional platinum amine complexes destabilize DNA …

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Cisplatin nmr

195Pt‐ and 15N‐NMR Spectroscopic Studies of Cisplatin Reactions …

WebJan 4, 2011 · Abstract. The influences of solvent effects and dynamic averaging on the 195 Pt NMR shielding and chemical shifts of cisplatin and three cisplatin derivatives in … WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck …

Cisplatin nmr

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WebIntroduction. Cisplatin (cis-diamminedichloroplatinum(II)) is one of the most widely used first-line chemotherapeutic agents for a broad range of cancers.Cisplatin continues to be in widespread clinical use for various solid tumors such as ovarian, testicular, bladder, head and neck, and non-small cell lung cancers 1,2 but its usefulness is limited due to its high … WebFeb 1, 2007 · The paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum …

WebIt has been shown that the WP04 functional in combination with moderate basic sets 6-31G(d) and SDD allows to calculate characteristics of 1H NMR-spectrum of metal complexes with ligands based on tetrazole derivatives with high accuracy, which can be WebSep 18, 2024 · National Center for Biotechnology Information

WebFeb 1, 2012 · Cisplatin, 1, was used as purchased (Sigma-Aldrich, St. Louis, MO). Stock solutions of the platinum compounds in distilled water, 1 and 3, or DPBS (Dulbecco's phosphate buffered saline) buffer, 4, were in the range of 40–650 μM. WebSep 9, 2024 · Response of Cisplatin Resistant Skov-3 Cells to [Pt ( O,O'-Acac) (γ-Acac) (DMS)] Treatment Revealed by a Metabolomic ¹H-NMR Study Response of Cisplatin Resistant Skov-3 Cells to [Pt ( O,O' -Acac) (γ-Acac) (DMS)] Treatment Revealed by a Metabolomic ¹H-NMR Study 2024 Sep 9;23 (9):2301. doi: 10.3390/molecules23092301. …

WebMay 1, 2024 · The equilibrium structures of cisplatin and transplatin were optimized, and their 1 H, 15 N, and 195 Pt NMR chemical shifts were evaluated at both non-relativistic and fully relativistic four-component levels. Reliable correlations with experimental data were achieved at the DFT level with taking into account relativistic effects in calculations of …

WebSep 25, 2024 · The confirmation of bioconjugation of cisplatin with B-GNPs was done by UV-Visible spectroscopy, TEM, FTIR, 2D 1 H NMR DOSY and ICP-MS. Further, it was found that almost ~4 cisplatin molecules ... aspirasi karir adalahWebThe paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum compounds and nucleic acid constituents. The latest NMR … aspirasi karir 5 tahun kedepanWebFeb 9, 2001 · Our studies on STEALTH cisplatin show that NMR is a powerful tool in the characterization of drug-lipid interactions, the physical state of the drug inside the … aspirasi karir kedepannyaWebPt NMR shows that cisplatin is not produced in the reaction medium. Although the Pt(II) products bind to closed circular DNA, their effect on the mobility of Form I DNA is different from that produced by cisplatin. When physiolog-ical carbonate is present in the reduction medium, 13. C NMR shows that Pt(II) carbonato complexes form aspirasi kedokteranWebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... aspirasi kerajaanaspirasi keluargaWebOct 3, 2013 · In this work, 1H high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was used to characterize the variations in the metabolome (small metabolites and mobile lipids) of A549 human lung cells in response to exposure to the alkylating drug cisplatin. Multivariate analysis and signal integration of … aspirasi karir karyawan