Ctcf zinc finger folding cristallography
WebAug 1, 2024 · A CTCF domain sgRNA library screening identifies the zinc finger (ZF) domain as the region within CTCF with the most functional relevance, including ZFs 1 and 10. WebDec 31, 2016 · The linker domains of the CTCF zinc finger domain were found to be phosphorylated during mitosis. The phosphorylation of linker domains impaired the DNA-binding activity in vitro. Mutation analyses showed that amino acid residues (Thr289, Thr317, Thr346, Thr374, Ser402, Ser461, and Thr518) located in the linker domains …
Ctcf zinc finger folding cristallography
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WebDifferent subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites. Sequence similarities. Belongs to the CTCF zinc-finger protein family. Curated. Keywords. Domain. #Repeat; #Zinc-finger; Phylogenomic databases. GeneTree. ENSGT00940000156672; HOGENOM. CLU_002678_77_1_1; … WebCTCF is an evolutionarily conserved zinc finger (ZF) phosphoprotein that binds through combinatorial use of its 11 ZFs to ∼50 bp target sites that have remarkable sequence variation. Formation of different CTCF–DNA complexes, some of which are methylation-sensitive, results in distinct functions, including gene activation, repression, silencing and …
WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only present in the testis. However, it is also aberrantly expressed in many cancers. While it is known that shared and unique zinc finger sequences in CTCF and CTCFL … Web5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic …
WebSep 13, 2024 · An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol. Cell ... WebSep 8, 2024 · CTCF is an 11-zinc-finger DNA-binding protein that acts as a transcriptional repressor and insulator as well as an architectural protein required for 3D genome …
WebJun 5, 2015 · CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator ...
WebJul 29, 2024 · The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding … health 252 liberty universityWebApr 15, 2016 · CTCF, a zinc-finger binding protein, is involved in chromosome folding and the insulation of TADs [91], and then the transition from totipotency to pluripotency is marked by the accumulation of ... golf duck hook fixWebHowever, the 3′ end of the CTCF motif is occupied by the N-terminal CTCF zinc fingers , and cohesin appears to bind the CTCF C terminus . Finally, CTCF may form local secondary DNA structures ( 83 ), which have been invoked to account for the directionality of loop formation between CTCF binding sites ( 102 ). golf dufferin heights reservationWebTranscription from the amyloid precursor protein (APP) promoter is largely dependent on a nuclear factor binding site designated as APBβ. The protein that binds to this site is the … health 263WebCTCF is also a tumour suppressor frequently mutated in cancer, however, the structural and functional impact of mutations have not been examined. We performed molecular and … health 255 cal polyWebMar 1, 2012 · The linker domains of the CTCF zinc finger domain were found to be phosphorylated during mitosis. The phosphorylation of linker domains impaired the … golf dumoulinWebCTCF is a multivalent transcription factor and uses different combinations of zinc fingers (ZFs) to bind diverse target sequences . Tumor-derived point mutations in ZF3 and ZF7 … health24.ua