Web23 jun. 2015 · Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause a characteristic defect in epithelial ion transport that plays a central role in the pathogenesis of cystic fibrosis (CF). Hence, pharmacological correction of this ion transport defect by targeting of mutant CFTR, or alternative ion channels that may … WebThe cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel regulated by cAMP-dependent phosphorylation, which is expressed in epithelial cells of a wide variety of tissues including the reproductive tract. From: Comprehensive Biomaterials, 2011 Add to Mendeley About this page
CFTR Protein: Not Just a Chloride Channel? - PubMed
Web9 mrt. 2024 · 2.1 Cardiac fibroblasts. There are a variety of cells in the heart, they contain cardiomyocytes, fibroblasts, endothelial cells and smooth muscle cells, of which fibroblasts are the most, accounting for about 75% (Eghbali, 1992; Camelliti et al., 2005; Nemoto et al., 2024).Their main functions are to produce and maintain the homeostasis of myocardial … WebCFTR (cystic fibrosis transmembrane conductance regulator) is an integral membrane protein that functions as an epithelial Cl − channel, which is rendered defective by inherited gene mutations in patients with cystic fibrosis (Riordan et al. 1989).Its function underlies fluid secretion in the airways, sweat ducts, pancreatic duct, and vas deferens, and it … evga mouse x17 software
CFTR - Johns Hopkins Cystic Fibrosis Center
WebIon channels are protein molecules that span across the cell membrane allowing the passage of ions from one side of the membrane to the other. They have an aqueous … Web13 apr. 2012 · Mutations in the gene-encoding cystic fibrosis transmembrane conductance regulator (CFTR) cause defective transepithelial transport of chloride (Cl−) ions and fluid, thereby becoming responsible for the onset of cystic fibrosis (CF). One strategy to reduce the pathophysiology associated with CF is to increase Cl− transport through alternative … Web29 jan. 2024 · The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although CF pathogenesis … evga next gen graphics