WebFeb 1, 2024 · The level of histone lactylation is increased in tumors, which promotes the occurrence of tumors by promoting the expression of YTHDF2. It demonstrated the carcinogenic effect of histone lactylation, thus providing a new therapeutic target for the treatment of ocular melanoma [32]. In non-small cell lung cancer (NSCLC) cells, lactate … WebJan 19, 2024 · Lactate, an important metabolic product, might have some common functions relevant to proliferation in stem cells and cancer cells. The microenvironment …
Uncovering ubiquitous protein lactylation Nature Methods
WebAug 26, 2024 · Lactylation, being regulated by lactate, has recently been confirmed as a novel contributor to epigenetic landscape, not only opening a new era for in-depth … WebApr 15, 2024 · Lactylation Characteristics and functions of Kla Lactate-derived Kla is a newly identified PTM that closely couples metabolism, especially the ‘Warburg effect’, with epigenetic modification. Under lactate increases induced by hypoxia and bacterial challenges, histone Kla is stimulated and directly promotes gene transcription [ 21 ]. ews fish
Cells Free Full-Text On the Role of Glycolysis in Early ...
WebLactate accumulation from metabolic reorganization in cancer patients can replenish the TCA cycle; in this process, lactate mediates the expression of the relevant genes through histone lactylation, which then regulates tumor cell proliferation and may be responsible for the immune escape and poor clinical outcome of the tumor microenvironment … WebMay 5, 2024 · lactylation JAK-STAT Introduction The dysfunctional or exhausted states of tumor-infiltrating lymphocytes (TILs) lead to tumor immune evasion and further progression. Cancer immunotherapy has brought unprecedented success in clinical benefits for multiple types of cancer by reinvigorating the functions of TILs. WebFeb 1, 2024 · The glycolytic switch is adopted in malignant cells, where pyruvates are converted to lactates in the cytoplasm for excess biomass production to meet the high demands of fast cell proliferation. Histone lactylation is regulated by the level of lactate, and acetyl-CoA, functioning as the donor of the acetyl group, affects the level of acetylation. ewsfe