Web余发星团队与合作者在《Protein & Cell》报道RNF43在结直肠印戒细胞癌中发生高频突变. 结直肠癌是全球最常见的恶性肿瘤之一。. 由于缺乏有针对性的靶向疗法，结直肠癌目前已 … http://www.eeo.com.cn/2024/0321/378952.shtml

重组人RNF43蛋白(Fc Chimera) Abcam中文官网

A nuclear function for the protein has also been proposed but recently it was shown that this is an artifact, nuclear staining being an artifact of the antibodies employed [6]. Cancer-associated RNF43 mutations lead to activation of β-catenin signaling through aberrantly increasing Wnt-receptor levels at the membrane. See more Ring finger protein 43 is a protein that in humans is encoded by the RNF43 gene. See more The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate … See more • Yagyu R, Furukawa Y, Lin YM, Shimokawa T, Yamamura T, Nakamura Y (November 2004). "A novel oncoprotein RNF43 functions in an … See more WebRNF43作为经典Wnt通路的负调节因子,可泛素化赖氨酸残基降解Frizzled受体,起到抑制肿瘤发生、进展的作用。多个研究表明肿瘤抑癌基因RNF43在子宫内膜癌(Endometrial … messages archives outlook

RNF43 Mutation - My Cancer Genome

WebRNF43 expression was commonly decreased in ccRCC specimens, and low expression of RNF43 indicated a higher TNM stage, SSIGN score, and WHO/ISUP grade and short … WebNov 23, 2024 · 总的来说，该研究揭示了rnf43突变在预测治疗反应和患者生存期方面的价值。在mcrcbraf-v600e患者群体中，rnf43功能缺失突变的发生与orr的改善相关。 WebAbTACs recruit RNF43 to internalize cell-surface proteins. (a) Graphical representation of the AbTAC mode of action. (b−d) Engineered RNF43 constructs and the GFP-Nanoluciferase reporter with their corresponding confocal microscopy images showing GFP localization for each experimental condition. (b) Anti-GCN4-RNF43 fusion as an isotype control. messages are not showing up on iphone